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The Good There is strong evidence of a relationship between blood lipids and other nutrients, and research showing good results in treating depression with nutrition. For many people, changes in diet, exercise, and supplementation can have a dramatic impact on depression. *

The Not-So-Good
 Depression is a particularly complex health topic, with many potential causes. William Walsh, PhD, has worked over many years to understand and categorize the metabolic causes of depression. He has found that there are several primary metabolic types associated with depression, each requiring a different (sometimes opposite) approach. A summary of his work is here; those not interested in  the details will find the types described in the article's sidebars. His work has implications for all types of nutritional, herbal, and conventional therapies, but especially for depression.

So, it is especially important to get a full assessment of your diet, nutrition, health, life circumstance, and family history (ideally, in partnership with a nutrition-oriented doctor). Resolving depression can require changes in ones life circumstance (work/living environments, relationships) that might not be easy or likely. Depressed people often eat poorly, and otherwise fall into life patterns that only exacerbate their condition. If ones condition is severe enough, professional help could be important to break through the interia often associated with depression. And as with anxiety, be aware of how you breathe.

Commonly-prescribed anti-depressant drugs (SSRIs in particular) have been linked with increased suicide in teens. Loss of libido and other negative effects are common in adults.

Other Issues Despite the modern crusade against cholesterol, research shows that excessively low cholesterol can increase the likelihood of depression and stroke. Simplistic views of cholesterol that focus only on total cholesterol, or even the big four -- total, HDL, LDL, and triglycerides -- are potentially hazardous to your health and mood. See the Cholesterol page for general guidelines, and consider taking one of the more-sophisticated cholesterol tests that are now available. Also, do an overalll assessment of your lifestyle -- work,relationships, exercise, blood sugar, nutrition -- and make changes where needed, mindful of the highly-indivual nature of depression stessed above.

Depression Supplements Table The table below summarizes the current research for nutritional and lifestyle effects on depression, and provides one or more links to key research and related products. As always, this should be taken only as a general guideline. Anyone embarking on a nutritional/exercise regimen should work with a sympathetic doctor, particularly if medications are also involved.
 
Useful Nutrients A top-N list of supplements shown to help alleviate depression appears in the table below. But omega-3 fatty acids (fish/flax oil) and magnesium are important, and should be part of everyone's diet.

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Item Notes Research Item Link
magnesium Present in many nuts, but otherwise not that easy to get in ones diet. Research has shown almost miraculous results in treating depression with magnesium. The choices at the right include both a 1:1 cal-mag supplement and pure magnesium (capsule and powder). - magnesium '7-day cure' calcium-magnesium 1:1
magnesium capsules
lemon 'Calm' Mg powder
rasp/lemon Calm packets


omega-3 oilsFish oil has the best research support. Flax seed oil is a potential substitute, but can be poorly metabolized.- studyfish oil
B-complexResearch suggests that B-6, B-12, and folate have an impact on depression. Use a balanced, quality formula like the one cited here.- Finnish folate study
- B6 and depression
- B12 and depression
Jarrow B-complex
folic acid, .8 mg
Saint John's wort  Offers anti-depressant and anti-anxiety benefits. Not to be mixed with anti-depressant medication. Recent 'news' of 'no supporting research' is nonsense. - SJW review (2000)
- SJW vs. Paxil (2005)
-SJWand depression
St John's wort
CurcuminIn limited research, has shown solid benefits against stress and depresssion. Note that the new Life Extension Super Bio-Curcumin has shown excellent absorption without requiring piperine (see piperine/Bioperine concerns).- Chinese study
- curcumin summary
LE  Super Bio-Curcumin
curcumin w/ Bioperine
full-spectrum turmeric
sam-EVery effective in research. One caveat:  a very small percentage of people  become more depressed, or manic on sam-E. Per Dr. Walsh's observations above, be mindful of the effects of any supplement or dietary change for you, and use what works - studyquality Sam-E
lemon balm (melissa) Shows benefits for mental clarity, mood, and Alzheimer's disease. Like other members of the mint family (though equally invasive), lemon balm is a good grow-your-own candidate. - lemon balm and theanine
- lemon balm summary
lemon balm leaf
LE Natural Stress Relief Formula
probioticsResearch suggests that intestinal flora can play a major role in depression. Probiotics are inexpensive and generally beneficial for health as well  Primal Defense is top-of-the-line, but not cheap..- probiotics for stress/depressionprobiotics formula
Primal Defense

Life Extension Products
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Please note that this information is for educational purposes only and does not represent any form of medical advice. Statements made here have not been evaluated by the FDA. Product discussion here is not intended to diagnose, treat, cure, or prevent any disease. Users are encouraged to work with a nutritionally-oriented doctor before embracing a nutritional or herbal regime.

Depression