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| Item | Notes | Research | Item Link |
| resveratrol | Believed to be the source of the French (health) Paradox, and found in the fabled Chinese longevity herb Fo-Ti. Thought to produce calorie-restriction anti-aging effects without a starvation diet! Stability of reservatrol is a question - get the newer stabilized form. Research suggests large doses (>100 mg/day) are required for best anti-aging effects (though benefits are shown for much smaller doses). | animal study | trans-resveratrol, 100mg resveratrol + grape seed extract |
| benfotiamine | A potent inhibitor of advanced glycation endproducts (AGEs), considered major culprits in the aging process. | survey benfotiamine & vaso/nerve aging long summary of benfotiamine research and benefits |
benfotiamine |
| ashwagandha | Numerous benefits, including brain health, vitality, and anti-cancer properties. But for anti-aging, shows specific anti-glycation effects. | ashwagandha
.vs glycation |
Sensoril ashwagandha |
| r-lipoic acid | A powerful anti-oxidant with many benefits. Take with biotin, which lipoic acid can compete with. R-lipoic has better research support than the alpha-lipoic version . Get the 'stabilized' version, which has longer shelf life and absorbs much better than ordinary ALA or RLA. Best taken on an empty stomach with a glass of water, not at the same time as acetyl l-carnitine. | ala and aging, diabetes alc and ala |
stabilized r-lipoic acid |
| acetyl-l-carnitine | Good for brain and celular metabolism. Combined with lipoic acid, reversed animal aging in one study. The arginate variant shows stronger brain benefits. | anti-aging supplements alc and aging |
acetyl l-carnitine alc arginate |
| milk thistle (silymarin) | An antioxidant and immune stimulnt, long valued as an excellent liver and kidney tonic, Silymarin has also shown anti-aging properties similar to resveratrol. Some life-extensionists take resveratrol in the morning (since it is mildly stimulating) and silymarin at night. Silymarin is poorly absorbed, so favor Siliphos or another absorption-enhanced variety. | longevity: tehcnical discussion and research reference on sirtuins and silymarin | siliphos LE Mega-Silymarin |
| vitamin D | Research on D and longevity is still somewhat thin, but the evidence that D benefits immune function is building, and D's relation to bone health has long been established. There is also recent evidence that D helps to increase HDL and might inhbit cancer. Supplementation is especially important when ones exposure to sunlight is limited. Use the D3 variety. | vitamin D3 | |
| carnosine | Slows protein cross-linking in studies, one component of aging. | carnosine
and aging carnosine and age-related disease |
carnosine |
| coenzyme q-10 | Diminishes with age, and implicated in so many health issues that it seems a no-brainer. The ubiquinol form seems to be best absorbed. | coenzyme Q-10 | |
| multi-vitamin | As complete as possible. If you can stand taking nine tablets a day, get Life Extension's multi . Otherwise, opt for Life Force which is a very good formula (though see the caveats about piperine/bioperine). | Life
Force (iron-free tablets) LIFE EXTENSION MIX 315 TABLETS |
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| multi-vitamin adjunct | Mostly the oil-based compounds that don't fit in a dry multi. Another Life Extension exclusive (and winner). | Life Extension Super Booster |
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| antioxidants | A blend including green tea and berry extracts is a good base. Good old Vitamin C, too. | NOW berry blend berry green Blueberry extract and pomegranate C complex C plus dihydroquercetin |
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| calcium-magnesium | Important for bone and heart health in particular. Choose a complex, not pure Ca Carbonate/Mg Oxide. | calcium-magnesium 1:1 | |
| anti-aging complex |
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Longevity
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